https://doi.org/10.4081/acbr.2021.159

Clinical features, severity, and outcomes of patients with COVID-19 infection: A follow-up study

Vol. 2 No. 2 (2021)
Submitted: 9 August 2021
Accepted: 10 September 2021
Published: 11 October 2021
COVID-19, disease severity, outcome assessment
Abstract Views: 348
PDF: 145
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Authors

Deldar Morad Abdulah
deldarmorad@gmail.com
Community and Maternity Health Unit, College of Nursing, University of Duhok-Iraqi Kurdistan, Duhok City, Iraq.
Hemin Khalid Saber
Department of Medicine, College of Medicine, Hawler Medical University, Iraqi Kurdistan, Erbil City, Iraq.

Few epidemiological investigations explored disease outcomes in patients with COVID-19 in Iraqi Kurdistan. The association of clinical and epidemiological characteristics of COVID-19 patients with outcomes was examined in this study. Patients who were diagnosed with COVID-19 from a private clinic were followed up until recovery or death between 15th August and 20th October 2020. The mean age of the COVID-19 patients was 47.12 (6-90 years). Fatigue (76.15%), myalgia (66.53%), fever (65.33%), cough (62.53%), sweating (58.52%), and headache (56.11%) were the most prevalent symptoms. Most of the patients had mild severity (350, 70.14%) followed by moderate (74, 14.83%), severe (46, 9.22%), and critical (29, 5.81%). The case fatality rate (CFR) was 5.41% (n=27) and was significantly increased with increasing severity; mild (0.0%), moderate (1.35%), severe (10.87%), and critical (72.41%; P<0.001). The patients with the critical and severe situations were significantly older; medians: 67 vs 55 years compared to those patients with moderate and mild situations; medians: 51 vs 45 years; P<0.001. The patients who died were significantly older compared to recovered patients; medians: 65 vs 46 years; P<0.001, respectively. The disease severity was the only factor to predict mortality in patients with COVID-19 disease. Concerning the severity, being older, having anorexia, fatigue, pleurisy, diarrhea, fever, sweating, shortness of breath, and being male were determined to be predictors of severity in COVID-19 patients. The incidence rate of severe/critical conditions was significantly increased with increasing age. The older age was determined to be a predictor for higher mortality.

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Scopus
Google Scholar
Europe PMC
Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382:727-33. DOI: https://doi.org/10.1056/NEJMoa2001017
Abdulah DM, Qazli SSA, Suleman SK. Response of the Public to Preventive Measures of COVID-19 in Iraqi Kurdistan. Disaster Med Public Health Prep 2020:1-9. DOI: https://doi.org/10.1017/dmp.2020.233
World Health Organization. WHO Coronavirus Disease (COVID-19) Dashboard: World Health Organization; 2020. Accessed: 24 June 2021. Available from: https://covid19.who.int/
Nacoti M, Ciocca A, Giupponi A, et al. At the epicenter of the Covid-19 pandemic and humanitarian crises in italy: changing perspectives on preparation and mitigation. NEJM Catalyst Innovations in Care Delivery 2020;1.
Kurdistan Regional Govrnment. Situation update Coronavirus (COVID-19), What the KRG is doing 2020. Available from: https://gov.krd/coronavirus-en/situation-update/
Cucinotta D, Vanelli M. WHO declares COVID-19 a pandemic. Acta Bio-medica: Atenei Parmensis 2020;91:157-60.
Adhikari SP, Meng S, Wu Y-J, et al. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. Infect Dis Poverty 2020;9:1-12. DOI: https://doi.org/10.1186/s40249-020-00646-x
Centers for Disease Control and Prevention, 2021. Underlying medical conditions associated with high risk for severe COVID-19: Information for healthcare providers. Avaliable from: https://www.cdc. gov/coronavirus/2019-ncov/hcp/clinical-care/underlyingconditions.html
Kolifarhood G, Aghaali M, Mozafar Saadati H, et al. Epidemiological and clinical aspects of COVID-19; a narrative review. Arch Acad Emerg Med 2020;8:e41.
Zou L, Ruan F, Huang M, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. New Engl J Med 2020;382:1177-9. DOI: https://doi.org/10.1056/NEJMc2001737
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet 2020;395:507-13. DOI: https://doi.org/10.1016/S0140-6736(20)30211-7
Dulloo AG, Jacquet J, Solinas G, et al. Body composition phenotypes in pathways to obesity and the metabolic syndrome. Internat J Obesity 2010;34:S4-7. DOI: https://doi.org/10.1038/ijo.2010.234
World Health Organization. Global surveillance for COVID-19 disease caused by human infection with the 2019 novel coronavirus, Interim guidance, 27 February 2020. WHO, 2020. Available from: https://apps.who.int/iris/handle/10665/331231
Merza MA, Al Mezori AAH, Mohammed HM, Abdulah DM. COVID-19 outbreak in Iraqi Kurdistan: The first report characterizing epidemiological, clinical, laboratory, and radiological findings of the disease. Diab Metabol Syndr 2020;14:547-54. DOI: https://doi.org/10.1016/j.dsx.2020.04.047
Ciceri F, Castagna A, Rovere-Querini P, et al. Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy. Clin Immunol 2020;217:108509. DOI: https://doi.org/10.1016/j.clim.2020.108509
Guan W-j, Ni Z-y, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. New Engl J Med 2020;382:1708-20. DOI: https://doi.org/10.1056/NEJMoa2002032
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054-62. DOI: https://doi.org/10.1016/S0140-6736(20)30566-3
Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA 2020;323:2052-59. DOI: https://doi.org/10.1001/jama.2020.6775
Palaiodimos L, Kokkinidis DG, Li W, et al. Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York. Metabolism 2020;108:154262. DOI: https://doi.org/10.1016/j.metabol.2020.154262
Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA 2020;323:1061-9. DOI: https://doi.org/10.1001/jama.2020.1585
Sun P, Qie S, Liu Z, et al. Clinical characteristics of hospitalized patients with SARS‐CoV‐2 infection: a single arm meta‐analysis. J Med Virol 2020;92:612-17. DOI: https://doi.org/10.1002/jmv.25735
Grant MC, Geoghegan L, Arbyn M, et al. The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries. PLoS One 2020;15:e0234765. DOI: https://doi.org/10.1371/journal.pone.0234765
Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020;8:475-81. DOI: https://doi.org/10.1016/S2213-2600(20)30079-5
Ganatra S, Hammond SP, Nohria A. The novel coronavirus disease (COVID-19) threat for patients with cardiovascular disease and cancer. JACC CardioOncol 2020;2:350–55. DOI: https://doi.org/10.1016/j.jaccao.2020.03.001
Bagatini MD, Cardoso AM, Reschke CR, Carvalho FB. Immune system and chronic diseases 2018. J Immunol Res 2018;2018:1-2. DOI: https://doi.org/10.1155/2018/8653572
Ofori-Asenso R, Chin KL, Curtis AJ, et al. Recent patterns of multimorbidity among older adults in high-income countries. Population Health Manag 2019;22:127-37. DOI: https://doi.org/10.1089/pop.2018.0069
World Health Organization. Coronavirus disease 2019 (COVID-19): situation report, 72. WHO, 2020. Available from: https://covid19.who.int/
Abdulah DM, Hassan A. Relation of dietary factors with infection and mortality rates of COVID-19 across the world. J Nutrition Health Aging 2020:1-8. DOI: https://doi.org/10.1007/s12603-020-1434-0
Gasmi A, Noor S, Tippairote T, et al. Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic. Clinical Immunol 2020:108409. DOI: https://doi.org/10.1016/j.clim.2020.108409
Chandra RK. Nutrition and the immune system from birth to old age. Eur J Clinical Nutrition 2002;56:S73-6. DOI: https://doi.org/10.1038/sj.ejcn.1601492
Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K. Causes, consequences, and reversal of immune system aging. J Clinical Investig 2013;123:958-65. DOI: https://doi.org/10.1172/JCI64096

How to Cite

Abdulah, D. M., & Saber, H. K. . (2021). Clinical features, severity, and outcomes of patients with COVID-19 infection: A follow-up study. Annals of Clinical and Biomedical Research, 2(2). https://doi.org/10.4081/acbr.2021.159

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