https://doi.org/10.4081/acbr.2022.164

Blood group and its correlation with cardiovascular risk factors: A community survey

Vol. 3 No. 1 (2022)
Submitted: 14 October 2021
Accepted: 11 February 2022
Published: 8 March 2022
Blood group, rhesus, left ventricular hypertrophy, triglycerides, pulse pressure, systolic blood pressure
Abstract Views: 952
PDF: 183
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Opeyemi O. Oni
oniopeyemi64@gmail.com
https://orcid.org/0000-0002-2790-9834
Department of Medicine, Bowen University, Iwo, Nigeria.
Patience O. Akinwusi
Department of Medicine, Osun State University, Osogbo, Nigeria.
Kehinde Joyce Olufemi-Aworinde
Department of Haematology and Blood transfusion, Bowen University, Iwo, Nigeria.
Abiona O. Odeyemi
https://orcid.org/0000-0002-1670-7321
Department of Medicine, Bowen University, Iwo, Nigeria.
Idowu Ajibola
Department of Community Medicine, Bowen University, Iwo, Nigeria.
Oluwaseyi K. Israel
Department of Community Medicine, Bowen University, Iwo, Nigeria.
Gbenga M. Israel
Department of Medicine, Bowen University, Iwo, Nigeria.
Oluwabukola Ala
https://orcid.org/0000-0003-3227-4121
Department of Medicine, Bowen University, Iwo, Nigeria.
Joel O. Akande
Department of Chemical Pathology, Bowen University, Iwo, Nigeria.
Ayodele O. Aremu
Department of Community Medicine, Bowen University, Iwo, Nigeria.
Adewumi Durodola
https://orcid.org/0000-0002-1156-9177
Department of Family Medicine, Bowen University, Iwo, Nigeria.
James I. Owolabi
https://orcid.org/0000-0003-1372-203X
Department of Surgery, Bowen University, Iwo, Nigeria.

Cardiovascular disease is a leading cause of morbidity and mortality globally. Non-O blood groups have been shown to confer a high risk of coronary heart disease. There is paucity of data on the relationship between blood group and left ventricular hypertrophy, among other cardiovascular risk factors. A community-based study was done to evaluate the blood groups and their associations with conventional cardiovascular risk factors in Ejigbo. Anthropometry, blood pressure and other clinical variables were measured. Blood samples were taken for biochemical analysis for blood group typing, serum cholesterol and triglyceride assay. A 12- lead electrocardiogram was performed. The analysis was done using SPSS version 20 to determine possible relationships between the variables. Two hundred and six cases were recruited and analyzed. The prevalence of the various groups was as follows: A - 23%; B-31.4%; AB-4.4%; O-41.2%; rhesus-positive-92.7% and rhesus-negative-7.3%. Blood group B had similar systolic blood pressure (136.0±23.9 vs 137.3±22.3; p=0.726), higher Sokolow- Lyon voltage sum (3.3±1.1 vs 2.9±0.9; p=0.025) and serum triglycerides [14(21.9%) vs7(8.4%), p=0.021] than those with blood group O. Those with Rhesus Positive status had longer PR interval (169.3±25.4 vs 154.2±19.1; p value=0.055) and QRS duration (83.8±12.8 vs 78.4±7.6; p value=0.043) than those with Rhesus negative blood groups. Binary logistic regression revealed blood group B as an independent determinant of left ventricular hypertrophy( LVH) (OR: 3.028; p=0.012; 95% CI:1.275-7.192). Blood group B is a determinant of LVH. Rhesus positive status is associated with delayed electrical conduction through the myocardium.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
He M, Wolpin B, Rexrode K, Manson JE, Rimm E, Hu FB, et al. ABO blood group and risk of coronary heart disease in two prospective cohort studies. Arterioscler Thromb Vasc Biol 2012;32:2314–20. DOI: https://doi.org/10.1161/ATVBAHA.112.248757
Chen Z, Yang SH, Xu H, Li JJ. ABO blood group system and the coronary artery disease: An updated systematic review and meta-analysis. Sci Rep 2016;6:23250. DOI: https://doi.org/10.1038/srep23250
Wu O, Bayoumi N, Vickers MA, Clark P. ABO(H) blood groups and vascular disease: A systematic review and meta-analysis. J Thrombosis Haemostasis 2008;6:62–9. DOI: https://doi.org/10.1111/j.1538-7836.2007.02818.x
Xiaoying H, Qiao S, Hong Q, et al. [Association between ABO blood group and acute myocardial infarction]. Zhonghua Xin Xue Guan Bing Za Zhi 2015;43:785–7.
Pike MM, Larson NB, Wassel CL, et al. ABO blood group is associated with peripheral arterial disease in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA). Thromb Res 2017;153:1–6. DOI: https://doi.org/10.1016/j.thromres.2017.02.018
BA DM, Sow MS, Diack A, Dia K, Mboup MC, Fall PD, et al. Cardiovascular disease and ABO blood-groups in Africans. Are blood-group A individuals at higher risk of ischemic disease? A pilot study. Egypt Hear J 2017;69:229–34. DOI: https://doi.org/10.1016/j.ehj.2017.03.002
City Population. Ejigbo (Local Government Area, Nigeria) - Population Statistics, Charts, Map and Location. 2016. Accessed: Dec 14th,2021. Available from: https://www.citypopulation.de/php/nigeria-admin.php?adm2id=NGA030010
Akinwusi OP, Asekun-Ola EO, Adebimpe WO, et al. Cardiovascular risk factors and electrocardiographic pattern in two rural communities of Osun State in South West Nigeria. Curr Res Cardiol 2017;4:15. DOI: https://doi.org/10.4172/2368-0512.1000084
Chobanian AV. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. JAMA 2003;289:2560. DOI: https://doi.org/10.1001/jama.289.19.2560
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499–502. DOI: https://doi.org/10.1093/clinchem/18.6.499
Kavey R-E, Daniels SR, Lauer RM, et al. American Heart Association Guidelines for Primary Prevention of Atherosclerotic Cardiovascular Disease Beginning in Childhood. Circulation 2003;107:1562–6. DOI: https://doi.org/10.1161/01.CIR.0000061521.15730.6E
Sokolow M, Lyon TP. The ventricular complex in left ventricular hypertrophy as obtained by unipolar precordial and limb leads. Am Heart J 1949;37:161–86. DOI: https://doi.org/10.1016/0002-8703(49)90562-1
Casale PN, Devereux RB, Alonso DR, et al. Improved sex-specific criteria of left ventricular hypertrophy for clinical and computer interpretation of electrocardiograms: validation with autopsy findings. Circulation 1987;75:565–72. DOI: https://doi.org/10.1161/01.CIR.75.3.565
Verdecchia P, Schillaci G, Borgioni C, et al. Prognostic value of a new electrocardiographic method for diagnosis of left ventricular hypertrophy in essential hypertension. J Am Coll Cardiol 1998;31:383–90. DOI: https://doi.org/10.1016/S0735-1097(97)00493-2
Gubner R, Ungerleider HE. Electrocardiographic criteria of left ventricular hypertrophy: factors determining the evolution of the electrocardiographic patterns in hypertrophy and bundle branch block. Arch Intern Med 1943;72:196–209. DOI: https://doi.org/10.1001/archinte.1943.00210080052005
Romhilt DW, Estes EH. A point-score system for the ECG diagnosis of left ventricular hypertrophy. Am Heart J 1968;75:752–8. DOI: https://doi.org/10.1016/0002-8703(68)90035-5
Sundström J, Lind L, Vessby B, et al. Dyslipidemia and an unfavorable fatty acid profile predict left ventricular hypertrophy 20 years later. Circulation 2001;103:836–41. DOI: https://doi.org/10.1161/01.CIR.103.6.836
Franchini M, Lippi G. The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer. BMC Medicine 2015;13:7. DOI: https://doi.org/10.1186/s12916-014-0250-y
Zhang H, Mooney CJ, Reilly MP. ABO Blood Groups and Cardiovascular Diseases. Int J Vasc Med 2012;2012:11. DOI: https://doi.org/10.1155/2012/641917
Gilmiyarova FN, Kolotyeva NA, Kuzmicheva VI, et al. Blood Group and Human Diseases (Review Of Literature). Russ Clin Lab Diagnostics 2020;65:216–21. DOI: https://doi.org/10.18821/0869-2084-2020-65-4-216-221
Cartron JP, Colin Y. Structural and functional diversity of blood group antigens. Transfus Clin Biol 2001;8:163–99. DOI: https://doi.org/10.1016/S1246-7820(01)00142-2
Wiggins KL, Smith NL, Glazer NL, et al. ABO genotype and risk of thrombotic events and hemorrhagic stroke. J Thromb Haemost 2009;7:263–9. DOI: https://doi.org/10.1111/j.1538-7836.2008.03243.x
Paquette M, Dufour R, Baass A. ABO blood group is a cardiovascular risk factor in patients with familial hypercholesterolemia. J Clin Lipidol 2018;12:383-389.e1. DOI: https://doi.org/10.1016/j.jacl.2017.12.001
Zhong GC, Liu S, Wu YL, et al. ABO blood group and risk of newly diagnosed nonalcoholic fatty liver disease: A case-control study in Han Chinese population. PLoS One 2019;14:e0225792. DOI: https://doi.org/10.1371/journal.pone.0225792
Palmieri V, Devereux R, Hollywood J, et al. Association of pulse pressure with cardiovascular outcome is independent of left ventricular hypertrophy and systolic dysfunction: the strong heart study. Am J Hypertens 2006;19:601–7. DOI: https://doi.org/10.1016/j.amjhyper.2005.12.009
Madhavan S, Ooi WL, Cohen H, Alderman MH. Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infarction. Hypertension 1994;23:395–401. DOI: https://doi.org/10.1161/01.HYP.23.3.395
Biswas S, Ghoshal PK, Halder B, Mandal N. Distribution of ABO blood group and major cardiovascular risk factors with coronary heart disease. Biomed Res Int 2013;2013:782941. DOI: https://doi.org/10.1155/2013/782941
Wazirali H, Ashfaque RA, Herzig JW. Association of blood group A with increased risk of coronary heart disease in the Pakistani population. Pak J Physiol 2005;1:1-2.
Lee HF, Lin YC, Lin CP, et al. Association of blood group A with coronary artery disease in young adults in Taiwan. Intern Med 2012;51:1815–20. DOI: https://doi.org/10.2169/internalmedicine.51.7173

How to Cite

Oni, O. O., Akinwusi, P. O., Olufemi-Aworinde, K. J., Odeyemi, A. O., Ajibola, I., Israel, O. K., … Owolabi, J. I. (2022). Blood group and its correlation with cardiovascular risk factors: A community survey. Annals of Clinical and Biomedical Research, 3(1). https://doi.org/10.4081/acbr.2022.164

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.