https://doi.org/10.4081/acbr.2021.138

Risk of dyslipidemia among children undergoing routine medical examinations in a secondary health care facility in Benin City, Edo State

Vol. 2 No. 1 (2021)
Submitted: 4 March 2021
Accepted: 2 April 2021
Published: 19 April 2021
Dyslipidemia, cholesterol, triglyceride, BMI, blood pressure
Abstract Views: 1338
PDF: 216
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Authors

Izehiuwa G. Enato
Department of Paediatrics, Nigeria.
Kingsley I. Akhimienho
Department of Paediatrics, Nigeria.
Kenneth Atoe
atoe.kenneth@edouniversity.edu.ng
https://orcid.org/0000-0001-7638-6040
Department of Chemical Pathology, Edo State University, Uzairue; Phytomedicine and Drug Discovery Unit, Department of Plant Biology and Biotechnology; Applied Environmental Bioscience and Public Research Group, University of Benin, Benin City, Nigeria, Nigeria.

Dyslipidemias in children are a diverse group of disorders that include monogenic disorders as well as dyslipidemias caused by a variety of factors. Although cholesterol levels in healthy children differ with age, a potential link to the development of dyslipidemia may be important to determine the likelihood of an early diagnosis. In this cross-sectional study, 220 seemingly healthy children aged 1 to 12 years were studied in Benin City, Nigeria, to determine the pattern of lipid profile. An enzymatic method was used to analyze serum lipids from blood samples obtained from the participants. The level of dispersion of data needed to assess the risk of early childhood dyslipidemia was described using the 95th percentile scale. In the 1-3 years old age group, at least 95 percent of the boys had total cholesterol levels below 132 mg/dL, compared to 124 mg/dL among the girls of the same age. Similarly, total cholesterol levels in the 7-9 year old age group were 127 mg/dL in boys and 110 mg/dL in girls. These levels could serve as a guideline for children of the study’s age group who appear to be in good health. Elevated triglycerides levels were found in male children under the age of three years, as well as in the 10-12 age brackets. Increases in triglycerides in the girls, on the other hand, were not age- or time-dependent. In general, the lipid profiles shown in the results were low, particularly in the 4-6 year old age group. A significant modifiable risk factor for cardiovascular disease in children is elevated lipid levels. The results of this study demonstrate the importance of routinely screening children for dyslipidemia. Elevated lipid levels are a major modifiable risk factor for cardiovascular disease in children. The findings of this research can be used as a basis for screening children for dyslipidemia because it provides a 95th percentile in lipid profiles of seemingly healthy children.

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Citations

Crossref
Scopus
Google Scholar
Europe PMC
WHO. World health statistics 2006. WHO Press, World Health Organization, Switzerland. 80p, 2006 (Accessed on March 10, 2015. Available from: https://www.who.int/gho/publications/world_health_statistics/whostat2006_erratareduce.pdf
Oguejiofor OC, Onwukwe CH, Odenigbo CU. Dyslipidemia in Nigeria: prevalence and pattern. Ann Afr Med 2012;11:197-202. DOI: https://doi.org/10.4103/1596-3519.102846
McGill HC Jr, McMahan CA, ZieskE AW, et al. Effect of non-lipid risk factors on atherosclerosis in youths with a favourable lipoprotein profile. Circulation 2001;103:1546-50. DOI: https://doi.org/10.1161/01.CIR.103.11.1546
Kavey REW, Daniel SR, Laver RM, et al. American Heart Association on guidelines for primary prevention of atherosclerotic cardiovascular disease beginning in childhood. Circulation 2003;107:1562-6. DOI: https://doi.org/10.1161/01.CIR.0000061521.15730.6E
Virkola K, Pesonem E, Akensblom HK, Siimes MA. Cholesterol and carotid artery wall in children and adolescents with familial hypercholesteronemia: a controlled study by ultrasound. Acta Pediatr 1997;86:1203-7. DOI: https://doi.org/10.1111/j.1651-2227.1997.tb14847.x
Hedly A, Ogden CL, Jhonson CL, et al. Prevalence of overweight and obesity amongst us childrean adolescents and adults, 1999-2002. JAMA 2004;291:2847-50. DOI: https://doi.org/10.1001/jama.291.23.2847
Kaudman JT, Wertenbricks S, Van des H, et al. Screening for risk factors for chronic diseases in children form fifteen countries. Prev Med 1981;10:121-32. DOI: https://doi.org/10.1016/0091-7435(81)90068-2
Khalol A, Gupta S, Madam A, et al. Serum lipid profile norms in indian children. Indian Pediator 1995,32:1177-80.
Allain CC, Poon LS, Chan CSG, et al. Enzymatic determination of Total Serum Cholesterol. Clinical Chemistry1974;20:470-5. DOI: https://doi.org/10.1093/clinchem/20.4.470
Akuyam SA, Isah HS, Ogala WN. Evaluation of serum lipid profile of under-five Nigerian children. Ann Afr Med 2007;6:119-23. DOI: https://doi.org/10.4103/1596-3519.55722
Shawar SM, Al-Bati NA, Al-Mahameed A, et al. Hypercholesterolemia among apparently healthy university students. Oman Med J 2012;27:274-80. DOI: https://doi.org/10.5001/omj.2012.69
Martínez DL, Pérez IP, Calvo MTM, et al. The Fuenlabrada study: lipids and lipoproteins in children and adolescents. An Esp Pediatr 1989;31:342-9.
Armstrong N, Balding J, Gentle P, Kirby B. Serum lipids and blood pressure in relation to age and sexual maturity. Ann Hum Biol 1992;19:477-87. DOI: https://doi.org/10.1080/03014469200002312
Dai S, Fulton JE, Harrist RB, Grunbaum JH, et al. Blood lipids in children: age-related patterns and association with body-fat indices: Project HeartBeat! Am J Prev Med 2009:37:S56-64. DOI: https://doi.org/10.1016/j.amepre.2009.04.012

How to Cite

Enato, I. G., Akhimienho, K. I., & Atoe, K. (2021). Risk of dyslipidemia among children undergoing routine medical examinations in a secondary health care facility in Benin City, Edo State. Annals of Clinical and Biomedical Research, 2(1). https://doi.org/10.4081/acbr.2021.138

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