https://doi.org/10.4081/acbr.2022.174

Vaccine hesitancy: Pattern of side effects of the first dose of AstraZeneca COVID-19 vaccine among healthcare workers in Enugu

Vol. 3 No. 1 (2022)
Submitted: 10 November 2021
Accepted: 7 February 2022
Published: 4 April 2022
COVID-19 virus, healthcare workers, Oxford-AstraZeneca vaccine
Abstract Views: 794
PDF: 140
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Authors

Emmanuel Chino Iyidobi
https://orcid.org/0000-0001-6499-724X
Department of Orthopaedics and Trauma, National Orthopaedic Hospital, Enugu, Nigeria.
Theclar Ogochukwu Iyidobi
toezigbo@yahoo.com
https://orcid.org/0000-0002-4206-469X
Department of Psychological Medicine, University of Nigeria Teaching Hospital, Ituku Ozalla Enugu, Nigeria.
Uche Sebastine Ozioko
Department of Orthopaedics and Trauma, National Orthopaedic Hospital, Enugu, Nigeria.
Justus Uchenna Onu
https://orcid.org/0000-0002-4567-7096
Department of Mental Health, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
Rosemary Chizobam Muomah
College of Medicine, University of Nigeria Enugu Campus, Nigeria.
Steven Kator Iorfa
https://orcid.org/0000-0002-5571-2713
Portsmouth Business School, University of Portsmouth, United Kingdom; Department of Psychology, University of Nigeria Nsukka, Nigeria.
Arinze Victor Aneke
Foundation Gracia Medical Clinics, Enugu, Nigeria.

Vaccination is a basic public health intervention and its advancement in prevention of infectious diseases that plague humans has been evolving and helps to save humanity from extinction. This study aims to evaluate the common side effects of AstraZeneca COVID-19 vaccine and willingness to receive second dose among healthcare workers within Enugu metropolis. It was a cross -sectional survey carried out from March to June, 2021 using validated self-administered questionnaire among 89 participants. Data analysis were conducted using SPSS version 21.0 (p<0.05). The median age of the participants was 38 years and 71 (79.8%) of them constitute the frontline health-workers. Post vaccination side effects was reported by 78 (87.6%) of the participant. Among the reported side effects, pain at the injection site was the most common 55 (62%) while sore throat, chills and rigor were the least occurring in 13 (14.6%) respectively. The association between the presence of side effect of Oxford AstraZeneca vaccine and willingness to receive the second dose of the vaccine was (p=1.00) while the duration and number of the side effects associated with the willingness to receive the second dose of the vaccine were not statistically significant (p>0.05) respectively. The Oxford AstraZeneca COVID-19 vaccine has high safety profile margin, though with some side-effects which could not deter participants from getting vaccinated. Education of the masses on safety of current vaccines and future vaccines should be an integral component of public health initiatives aimed at achieving the desired herd immunity.

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Citations

Crossref
Scopus
Google Scholar
Europe PMC
Bandyopadhyay S, Baticulon RE, Kadhum M, et al. Infection and mortality of healthcare workers worldwide from COVID-19: a systematic review. BMJ Global Health 2020;5:e003097. DOI: https://doi.org/10.1136/bmjgh-2020-003097
Ozioko US, Iyidobi EC, Ozioko MO, et al. The pattern of use of medical mask among health care professionals during COVID-19 pandemic in South East Nigeria University Teaching Hospital. Int J Infect Dis Ther 2020;8:81-7. DOI: https://doi.org/10.11648/j.ijidt.20200503.18
Masters PS. The molecular biology of coronavirus. Adv Virus Res 2006;66:193-292. DOI: https://doi.org/10.1016/S0065-3527(06)66005-3
Stadler K, Masignani V, Eickmann M, et al. SARS-beginning to understand a new virus. Nat Rev Microbiol 2003;1:209-18. DOI: https://doi.org/10.1038/nrmicro775
Enjuanes L, Zuniga S, Castano-Rodriguez C, et al. Molecular basis Coronavirus Virulence and Vaccine development. Adv Virus Res 2016;96:245-86. DOI: https://doi.org/10.1016/bs.aivir.2016.08.003
UNICEF. First COVID-19 COVAX vaccine doses administered to Africa. 2021. Accessed: 1st February, 2022. Available from: https://www.unicef.org/press-releases/first-covid-19-covax-vaccine-doses-administered-africa
National Primary Health Care Development Agency. COVID-19: Nigeria unveils strategy for effective, equitable vaccination. 2021. Accessed: 1st February 2021. Available from: https://nphcda.gov.ng/
Kerr S, Joy M, Torabi F, et al. First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales. PLoS Med 2022;19:e1003927.
Voysey M, Clemens SAC, Madhi SA, et al. Safety and efficacy of the ChAdOx1n COV-19 Vaccine against SARS COV-2. An interim analysis of four randomized control trial in Brazil, South Africa, and the UK. Lancet 2021;397:99-111. DOI: https://doi.org/10.1016/S0140-6736(20)32661-1
Krammer, F. SARS-CoV-2 vaccines in development. Nature 2020;586:516–527. DOI: https://doi.org/10.1038/s41586-020-2798-3
World Health Organization. Ten threats to global health 2019. Accessed: November 18, 2020. Available from: https://www.who.int/news-room/spotlight/ten-threats-to-global-health-in-2019
Yaqubo O, Castle- Clarke S, Sevadalis N, Chataway J. Attitude to vaccination: a critical review social science and medicine. Soc Sci Med 2014;112:1-11. DOI: https://doi.org/10.1016/j.socscimed.2014.04.018
Chapin-Bardales J, Gee J, Myers T. Reactogenecity Following Receipt of mRNA-Based COVID 19 Vaccines. JAMA 2021;325:2201. DOI: https://doi.org/10.1001/jama.2021.5374
Centers for Disease Control and Prevention (2021), Rapid Community Assessment Guide: Understand your community’s needs regarding COVID-19 vaccines. Available from: https://www.cdc.gov/vaccines/COVID-19/vaccinate-with-confidence/rca-guide/
Gee J, Marquez P, Su J, et al. First month of COVID-19 vaccine safety monitoring-United States. MMWR Morb Mortal Wkly Rep 2021;70:283. DOI: https://doi.org/10.15585/mmwr.mm7008e3
FDA Briefing Document. Pfizer- BioNTech COVID-19 Vaccine. Vaccine and Related Biological Products Advisory Committee Meeting, 2020. Accessed: 1st January, 2021. Available from: https://www.fda.gov/media/144245/download
National Primary Health Care Development Agency. COVID-19: Nigeria unveils strategy for effective, equitable vaccination2021. Accessed: 30th January, 2021. Available from: https://nphcda.gov.ng/
Taylor S, Landry CA, Paluszek MM, et al. The importance of understanding the motivational roots of vaccination hesitancy for SARS-CoV2. Front Psychol 2020;11:575950. DOI: https://doi.org/10.3389/fpsyg.2020.575950
Shekhar R, Sheikh AB, Upadhyay S, et al. COVID-19 vaccine acceptance among health care workers in the United States. Vaccines 2021;9:119. DOI: https://doi.org/10.3390/vaccines9020119
Zimmer C, Corum J, Wee S. Corona vaccine tracker. New York Times 2020. Available from: https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html
Bogdanov G, Bogdanov I, Kazandjieva J, Tsankov N. Cutaneous adverse effects of the available COVID-19 vaccines. Clinics Dermatology 2021;39:523–31. DOI: https://doi.org/10.1016/j.clindermatol.2021.04.001
Abu-Hammad O, Alduraidi H, Abu-Hammad S, et al. Side effect reported by Jordanian healthcare workers who received COVID 19 vaccines. Vaccines 2021;9:577. DOI: https://doi.org/10.3390/vaccines9060577
Jeskowiak I, Wiatrak B, Grosman- Dziewiszek P, Szelag A. The incidence and severity of post-vaccination reactions after vaccination reaction against COVID-19. Vaccines 2021;9:502. DOI: https://doi.org/10.3390/vaccines9050502
Menni C, Klaser K, May A, et al. Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in UK. A prospective observational study. Lancet Infect Dis 2021;21:939-49. DOI: https://doi.org/10.1016/S1473-3099(21)00224-3
Azimi M, Dehzad WM, Atiq MA, et al. Adverse effect of COVID 19 Vaccine reported by Lecturers and Staff of Kabul University of Medical Sciences, Kabul Afghanistan. Infect. Drug Resist 2021;14:4077-83. DOI: https://doi.org/10.2147/IDR.S332354
Freeman D, Loe BS, Chadwick A, et al. COVID-19 vaccine hesitancy in the UK: The Oxford coronavirus explanations, attitudes, and narratives survey (Oceans) II. Psychol Med 2021;1-5. DOI: https://doi.org/10.1017/S0033291720005188
Lin Y, Hu Z, Zhao Q, Alias H, et al. Understanding COVID-19 vaccine demand and hesitancy: A nationwide online survey in China. PLoS Negl Trop Dis 2020;4:e0008961. DOI: https://doi.org/10.1371/journal.pntd.0008961
Carpenter CJ. A meta-analysis of the effectiveness of health belief model variables in predicting behavior. Health Commun 2010;25;661-9. DOI: https://doi.org/10.1080/10410236.2010.521906
Jones CL, Jensen JD, Scherr CL, et al. The health belief model as an explanatory framework in communication research: exploring parallel, serial, and moderated mediation. Health Commun 2015;30:566-57 DOI: https://doi.org/10.1080/10410236.2013.873363

How to Cite

Iyidobi, E. C., Iyidobi, T. O. ., Ozioko, U. S. ., Onu, J. U. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ., Muomah, R. C. ., Iorfa, S. K., & Aneke, A. V. . (2022). Vaccine hesitancy: Pattern of side effects of the first dose of AstraZeneca COVID-19 vaccine among healthcare workers in Enugu. Annals of Clinical and Biomedical Research, 3(1). https://doi.org/10.4081/acbr.2022.174

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