https://doi.org/10.4081/acbr.2021.99

Assessment of serum uric acid levels in patients with cervical intraepithelial neoplasia in Benin City

Vol. 2 No. 1 (2021)
Submitted: 9 August 2020
Accepted: 22 January 2021
Published: 2 February 2021
Cervix, cancer, uric acid, neoplasia, metabolic medicine
Abstract Views: 1935
PDF: 185
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Authors

Kenneth Atoe
atoe.kenneth@edouniversity.edu.ng
https://orcid.org/0000-0001-7638-6040
Department of Chemical Pathology, Edo University, Iyamho, Edo State; Applied Environmental Bioscience and Public Research Group, University of Benin, Benin City; Phytomedicine and Drug Discovery Research Group, Department of Plant Biology and Biotechnology, University of Benin, Benin City, Nigeria.
Augustine Onovuakpo Eguvbe
https://orcid.org/0000-0002-2722-2186
Department of Chemical Pathology, Edo University, Iyamho, Edo State, Nigeria.

Elevated Uric acid levels in humans have been associated with cancer, though the pathogenic mechanism is still unclear. The present study attempts to investigate if elevated uric acid levels could be used to investigate the pre-malignant lesions leading to cervical cancer. The study which was carried out at the Department of Obstetrics and Gynaecology, University of Benin Teaching Hospital Benin City and Department of Chemical Pathology, Edo University Iyamho, Edo state Nigeria, between August, 2017 and January 2019, examined the capacity of detecting Cervical Intraepithelial Neoplasia (CIN) early with serum uric acid in order to increase the chances of survival of women at risk. A total of 197 female participants were recruited for the study. Based on histological diagnosis, they were grouped as CIN 1, CIN 2 and CIN 3. The control group were negative for CIN. Venous blood was obtained from participants and serum uric acid levels were determined using standard laboratory methods. The benchmark for serum uric acid levels in diagnosing CIN presented in this study was at 6.55 mg/dL. The probability that uric acid level higher than 6.55 mg/dL indicate the disease probabilty was 93.1%. The age category within the CIN group with the highest level of uric acid was 31-40 years (10.86 mg/dL). The use of serum uric acid as an excellent biomarker for the diagnosis of CIN is therefore suggested due to its high sensitivity.

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How to Cite

Atoe, K., & Eguvbe, A. O. (2021). Assessment of serum uric acid levels in patients with cervical intraepithelial neoplasia in Benin City. Annals of Clinical and Biomedical Research, 2(1). https://doi.org/10.4081/acbr.2021.99

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