Case Reports
Vol. 9 No. 1 (2026)
https://doi.org/10.4081/pjm.2026.540

Buschke-Löwenstein tumor of the vulva: case report and review of literature

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Received: 28 July 2025
Accepted: 23 September 2025
Published: 8 May 2026
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Buschke-Löwenstein tumor, human papilloma virus, giant condyloma acuminata

Authors

Hanifah D. Abubakar
https://orcid.org/0000-0001-9438-7733
Department of Obstetrics/Gynaecology, Northwest University/Muhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria.
Abdulrahman A. Bunawa
bunawa496@gmail.com
Department of Obstetrics/Gynaecology, Muhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria.

Human papillomavirus is a common sexually transmissible infection, often asymptomatic. Where it does present with symptoms, they range from self-limiting anogenital warts (in low-risk subtypes) to malignant transformation (in high-risk subtypes).

In extremely rare circumstances, anogenital warts can progress to become giant condyloma acuminata, a condition known as Buschke-Löwenstein Tumor (BLT).

BLT is a slow-growing locally aggressive, cauliflower-like benign tumor, with a tendency to malignant transformation. In some instances, it could co-exist with atypical epithelial cells or a well-differentiated squamous cell carcinoma. This tumor is usually resistant to conventional medical therapy for anogenital warts. Surgical resection is often the treatment modality, the extent of which depends on the extent of the lesion

We report a case of giant vulvar warts in a 17-year-old girl, who was successfully treated with skinning vulvectomy.

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1. Anuoro O, Bristow C, Jeffrey M, Klausner JD. Estimated prevalence of HPV among Nigerian women. A systematic review and meta analysis. Afr J Red Health 2022;26:89-96.
2. Walboomers JMM, Jacobs M, Manos M, et al. Human papilloma virus is a necessary cause of cervical cancer worldwide. The Journal of Pathology 1999;189:12-9. DOI: https://doi.org/10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
3. Lanitis T, Carroll S, O’ Mahony C, et al: The cost of managing genital warts in the UK. Int J STD AIDS 2012;23:189-94. DOI: https://doi.org/10.1258/ijsa.2011.011218
4. Levy A, Lebbe C. Buschke-Loweinstein tumor: diagnosis and treatment. Annales D’ Urologie 2006;40:175-8. DOI: https://doi.org/10.1016/j.anuro.2006.02.002
5. Franco L. Epidemiology of anogenital warts and cancer. Obstetrics and Gynecology Clinics of North America 1996;23:597-623. DOI: https://doi.org/10.1016/S0889-8545(05)70278-3
6. Irshad U, Puckett Y. Giant condylomata acuminata of Buschke and Lowenstein. 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560714/
7. Zekan J, Petrovic D, El Safadi S, et al. A surgical approach to giant condyloma (Buschke-Löwenstein tumour) with underlying superficial vulvar carcinoma: a case report. Oncology Letters 2013;5:541-3. DOI: https://doi.org/10.3892/ol.2012.1027
8. Knoblich R, Failing JF. Giant condyloma acuminatum (Buschke-Lowenstein tumor) of the rectum. American Journal of Clinical Pathology 1967;48:389-95. DOI: https://doi.org/10.1093/ajcp/48.4.389
9. Lilungulu A, Mpondo BCT, Mlwati A, et al. Giant Condyloma Acuminatum of vulva in an HIV-Infected Woman. Case Reports in Infectious Diseases 2017;2017:5161783. DOI: https://doi.org/10.1155/2017/5161783
10. Tripoli M, Cordova A, Maggì F, Moschella F. Giant condylomata (Buschke-Lowenstein tumours): our case loading surgical treatment and review of the current therapies. European Review for Medical and Pharmacological Sciences 2021;16:747-51.
11. Niazy F, Rostami K, Motabar AR. Giant Condyloma Acuminatum of vulva frustrating treatment challenge. World Journal of Plastic Surgery 2015;4:159-62.
12. Renzi A, Giordano P, Renzi G, et al. Buschke-Lowenstein tumor successful treatment by surgical excision alone: a case report. Surgical Innovation 2006;13:69-72. DOI: https://doi.org/10.1177/155335060601300111
13. Hum M, Chow U, Schuurmans N, Dytoc M. A case of giant condyloma acuminata successfully treated with imiquimoid 3.75% cream. SOMCR 2018;6:1-5. DOI: https://doi.org/10.1177/2050313X18802143
Abdulrahman A. Bunawa, Department of Obstetrics/Gynaecology, Muhammad Abdullahi Wase Teaching Hospital, Kano

senior Lecturer, department of Obstetrics and Gynaecology.

How to Cite



“Buschke-Löwenstein Tumor of the Vulva: Case Report and Review of Literature”. 2026. Pyramid Journal of Medicine 9 (1). https://doi.org/10.4081/pjm.2026.540.
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