https://doi.org/10.4081/aamr.2019.76

Transabdominal Doppler ultrasound evaluation of blood flow patterns of the uterine arteries in cervical cancer patients in Zaria, North-Western Nigeria

Vol. 2 No. 1 (2019)
Published: July 30, 2019
Cervical cancer, blood flow patterns, uterine arteries, transabdominal doppler
Abstract Views: 34
PDF: 12
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Authors

I. Garba
Department of Radiology, General Hospital, Minna, Niger State, Nigeria.
M.Z. Ibrahim
muibza@gmail.com
Department of Radiology, Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
S. Lawal
Department of Radiology, Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
N.D. Chom
Department of Radiology, Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
P.O. Ibinaiye
Department of Radiology, Ahmadu Bello University/Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.

Cervical cancer remains an important health issue especially in the developing countries that account for about 85% of the world burden of cervical cancer. Finding a role for Doppler ultrasound in the evaluation of these patients, may reduce the cost and improve access to management. This study was aimed at evaluating the Doppler flow parameters in patients with cervical cancer when compared to normal subjects. This was a prospective case control, descriptive and observational study conducted in radiology department, ABU Teaching Hospital, Zaria, Nigeria. Eighty-one patients with cervical cancer and 81 age-matched controls had transabdominal Doppler ultrasound examination of the main uterine arteries. The data was analyzed using SPSS version 20.0 Chicago Illinois USA. Difference between two groups was tested using student ttest and P<0.05 considered as statistically significant. The mean Resistivity Index (RI) and Pulsatility Index (PI) were significantly lower in patients with cervical cancer than the control (P<0.0001). The mean end diastolic velocity was significantly higher in patients than the control (P<0.0001). There was however no significant difference in the mean peak systolic velocity in patients and control (P=0.97). The findings have demonstrated that significant differences exist in the uterine artery Doppler flow parameters in patients with cervical cancer compared to the healthy controls. This emphasizes the role of Doppler scan in the evaluation and management of patients with cervical cancer.

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Citations

Crossref
Scopus
Google Scholar
Europe PMC
Ries LAG, Melbert D, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2004. National Cancer Institute. Bethesda, MD. Available from: http://seer.cancer.gov/csr/1975_2004/ Accessed on 15th June 2015.
WHO. Comprehensive Cervical Cancer Control. Available from http://www.who.int/reproductivehealth/publications/cancers/cervicalcancer-guide/en/ Accessed on October 2015.
Jacques F, Hai-Rim S, Freddie B, et al. Estimates of worldwide burden of cancer in 2008. Int J Cancer 2010;127:2893-17.
Walboomers JM, Jacobs MV, Manos MM, et al. Human papilloma virus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189:12-9.
WHO/ICO Information center of human papilloma virus and cervical cancer: human papilloma virus and related cancers in the world. Summary report 2010. Available from: http://www.who.int/hpvcentre/en. Accessed on 20th June 2015.
Willoughby BJ, Faulkner K, Stamp EC, Whitaker CJ. A descriptive study of the decline in cervical screening coverage rates in the North East and Yorkshire and the Humber regions of the UK from 1995-2005. J Public Health (Oxf) 2006;28: 355-60.
Kyari O, Nggada H, Mairiga A. Malignant tumours of female genital tract in north eastern Nigeria. East Afr Med J
;81:142-5.
Uzoigwe SA, Seleye-Fubara D. Cancer of the uterine cervix in Port Harcourt, Rivers State: a clinic-pathological review. Niger J Med 2004;13:110-3.
Yakasai IA, Ugwa EA, Otubu J. Gynaecological Malignancies in Aminu Kano Teaching Hospital Kano: A 3 year review. Nig J Clin Pract 2013;16:63-6.
Adewole IF, Edozien LC, Babarinsa IA, Akang EE. Invasive and in situ carcinoma of the cervix in young Nigerians. A clinic-pathologic study of 27 cases. Afr J Med Sci 1997;26:191-3.
Folkman J, Watson K, Ingler D, Hanahan D. Introduction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989;339:58-61.
Kidron D, Bernheim J, Aviram R, et al. Resistance to blood flow in ovarian tumours: correlation between resistance index and histological patterns of vascularisation. Ultrasound Obstet Gynecol 1999;13:425-30.
Kaku T, Hirakawa T, Kamura T, et al. Angiogenesis in the adenocarcinoma of the uterine cervix. Cancer 1998;83:1384-90.
Abulafiya O, Sherer DM. Angiogenesis in the uterine cervix. Int J Gynaecol Cancer 2000:349-57.
Obermair A, Wanner C, Bilgi S, et al. Tumour angiogenesis in stage 1B cervical cancer: Correllation of microvessel density with survival. Am J Obstet Gynaecol 1998;178:314-9.
Dinh TV, Hannigan EV, Smith ER, et al. Tumour angiogenesis as predictor of recurrence in stage 1b squamous cell carcinoma of the cervix. Gynecol Oncol 1996;87:751-4.
Taylor KJ, Ramos I, Cater D, et al. Correlation of Doppler ultrasound signals with neovascular morphologic features. Radiology 1998;166:57-62.

How to Cite

Garba, I., Ibrahim, M., Lawal, S., Chom, N., & Ibinaiye, P. (2019). Transabdominal Doppler ultrasound evaluation of blood flow patterns of the uterine arteries in cervical cancer patients in Zaria, North-Western Nigeria. Annals of African Medical Research, 2(1). https://doi.org/10.4081/aamr.2019.76

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