Evaluation of serum levels of iron, total iron binding capacity, transferrin saturation and ferritin in chronic kidney disease patients vs. control group

Published: March 17, 2020
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The magnitude of chronic renal disease is enormous, as the prevalence of kidney failure is rising. Anaemia is a common complication of chronic kidney disease (CKD) that develops early in its course and becomes increasingly severe as the disease progresses. The aim is to evaluate the serum level of iron, Total Iron Binding Capacity (TIBC), transferrin saturation and ferritin in chronic kidney disease population in Zaria and control subjects. This study was conducted at ABUTH Zaria were 125 patients in various stages of CKD who presented at the nephrology clinic and equal number of apparently healthy age and sex matched controls were recruited. The mean (SD) age of patient and controls were 48 (14) years. These were made up of 53.6% males, and 46.4% females. Mean values of serum creatinine significantly higher in the patients (<0.0001). There was no significant difference in the mean values of iron (p=0.32) and TIBC (p=1.29) in both study groups. The patients had a significantly (p˂0.0001) higher mean value for ferritin and TSAT than the control group. There were higher serum creatinine and ferritin values in males than in females while higher serum TIBC, estimated creatinine clearance and iron were observed in females than males. Serum creatinine, ferritin and estimated creatinine clearance of male patients were found to be significantly higher with p-value of 0.002, 0.000 and 0.028 respectively than that of female patients. No significant differences were noted in serum levels of iron, TIBC and TSAT. Serum creatinine, ferritin and TSAT were found to be significantly elevated in CKD patients while serum Iron and TIBC were not.

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Citations

Afolabi MO, Abioye-Kuteyi AE, Arogundade FA, Bello IS. Prevalence of chronic kidney disease in a Nigerian family practice population. South African Family Practice. 2009;51(2).
AIHW 2005. Chronic kidney disease in Australia, 2005. Australian Institute of Health and Welfare Cat. No. PHE 68. Canberra: AIHW. http://www.aihw.gov.au.
Levey AS, Coresh J. Should the K/DOQI definition of chronic kidney disease be changed? American journal of kidney diseases. 2003 Oct 1;42(4):626-30.
Foundation NK. KDOQI clinical practice guideline for diabetes and CKD: 2012 update. American Journal of Kidney Diseases. 2012 Nov 1;60(5):850-86.
Weiss G. Iron metabolism in the anemia of chronic disease. Biochimica et Biophysica Acta (BBA)-General Subjects. 2009 Jul 1;1790(7):682-93.
Oyejide CO. Health research methods for developing country scientists. Leniks Limited; 1992.
Woods J, Mellon M. Thiocyanate method for iron: a spectrophotometric study. Industrial & Engineering Chemistry Analytical Edition. 1941 Aug 1;13(8):551-4.
Yee HY, Zin A. An AutoAnalyzer procedure for serum iron and total iron-binding capacity, with use of ferrozine. Clinical chemistry. 1971 Sep 1;17(9):950-3.
Hoffman DR. Estimation of serum IgE by an enzyme-linked immunosorbent assay (ELISA). Journal of Allergy and Clinical Immunology. 1973 May 1;51(5):303-7.
Slot C. Plasma creatinine determination a new and specific Jaffe reaction method. Scandinavian journal of clinical and laboratory investigation. 1965 Jan 1;17(4):381-7.
Alebiosu CO, Ayodele OO, Abbas A, Olutoyin AI. Chronic renal failure at the Olabisi Onabanjo university teaching hospital, Sagamu, Nigeria. African health sciences. 2006;6(3):132-8.
Ulasi II, Ijoma CK. The enormity of chronic kidney disease in Nigeria: the situation in a teaching hospital in South-East Nigeria. Journal of tropical medicine. 2010;2010.
Gangadhar T, Srikanth P, Suneetha Y. Predictive value of iron store markers in anemia of chronic kidney disease. Journal of Chemical and Pharmaceutical Research. 2010;2(3):400-10.
Gotloib L, Silverberg D, Fudin R, Shostak A. Iron deficiency is a common cause of anemia in chronic kidney disease and can often be corrected with intravenous iron. Journal of nephrology. 2006;19(2):161-7.
Juma A. Prevalence of Anemia and its associated factors in patients with Chronic Kidney Disease at Muhimbili National Hospital Dar es Salaam (Doctoral dissertation, Muhimbili University of health and Allied Sciences).
Hsu CY, McCulloch CE, Curhan GC. Iron status and hemoglobin level in chronic renal insufficiency. Journal of the American Society of Nephrology. 2002 Nov 1;13(11):2783-6.

How to Cite

Suleiman, H. M. ., Amina, M. ., Abubakar, I. ., Rasheed, Y. ., El-Bashir, M. J. ., Manu, M. ., … Bashir, A. D. . (2020). Evaluation of serum levels of iron, total iron binding capacity, transferrin saturation and ferritin in chronic kidney disease patients vs. control group. Annals of African Medical Research, 2(2). https://doi.org/10.4081/aamr.2019.101