Spectrum of Pediatric Endocrine Disorders at the Aminu Kano Teaching Hospital, Kano, Northwestern Nigeria: a five-year review

Submitted: 13 March 2023
Accepted: 8 April 2023
Published: 11 August 2023
Abstract Views: 143
PDF: 79
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

In many developing countries, including Nigeria, non-communicable diseases, such as endocrine disorders, are not given much attention because of the enormous burden posed by infectious diseases like malaria, tuberculosis, and other childhood killer diseases. In addition, endocrine disorders are thought to be uncommon due to a lack of specialized screening facilities and trained healthcare professionals to diagnose and manage these endocrine diseases. This study aims at defining the burden of pediatric endocrine disorders (PEDs )in Kano. A review of records of children who presented at the pediatric endocrine unit of Aminu Kano Teaching Hospital with pediatric endocrine disorders from 2018 to 2022 was carried out. A total of 6,314 new pediatric cases were seen during the study period, and 178 of these were pediatric endocrine disorders accounting for 2.8% of the total. The mean age of all the cases at presentation was 6.35±4.95 years, and male to female ratio was 1:1.3. Disorders of endocrine pancreas/lipids metabolism (68/178, 38%) were the commonest, followed by thyroid disorders (23/178, 12.9%) and pubertal disorders (16/178, 9%) respectively. Other disorders seen were calcium, phosphate metabolism, and bone disorders (15/178, 8.4%), syndromes (genetic syndromes/ multiple congenital abnormalities) with endocrine system involvement (13/178, 7.3%), adrenal disorders (10/178, 5.1%) and disorders of energy balance (6/178, 3.4%). More females presented with disorders of the pancreas/lipids, thyroid, precocious puberty, and congenital adrenal hyperplasia. The highest number of cases was seen in the last year of review, while the lowest was in the third year of review. Type 1 diabetes mellitus and disorders involving the thyroid gland, pubertal development, adrenal gland, and bone were the five leading groups of childhood endocrine disorders encountered in our clinical practice at Aminu Kano Teaching Hospital.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

HM Goodman. Introduction. In: Basic Medical Endocrinology. Raven Press, New York, USA. 1988. p.1–25 DOI: https://doi.org/10.1016/B978-0-12-373975-9.00001-X
GA Hedge, HD Colb, RL Goodman. General principles of endocrinology. In Clinical Endocrine Physiology, WB Saunders Co., Philadelphia, USA. 1987. p. 3–33.
M Zacharin, JP Chanoine, F Cassorla, et al. Promoting excellence in the care of pediatric endocrine diseases in the developing world. Pediatrics 2013;131:573–8. DOI: https://doi.org/10.1542/peds.2012-0848
DB Dunger, MA Sperling, CL Acerini, et al. European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents. Pediatrics 2004;113:133–40. DOI: https://doi.org/10.1542/peds.113.2.e133
P Cohen, AD Rogol, CL Deal, et al. Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop. Journal of Clinical Endocrinology and Metabolism 2008;93: 4210–7. DOI: https://doi.org/10.1210/jc.2008-0509
J L´eger, A Olivieri, M Donaldson, et al. European society for paediatric endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. Hormone Research in Paediatrics 2014;81:80–103. DOI: https://doi.org/10.1159/000358198
UNAIDS, WHO. AIDS epidemic update: December 2005. Available from: https://data.unaids.org/publications/irc-pub06/epi_update2005_en.pdf
R Snow, C Guerra, A Noor, et al. The global distribution of clinical episodes of plasmodium falciparum malaria. Nature 2005;434:214-7. DOI: https://doi.org/10.1038/nature03342
ES Majaliwa, BEJ Elusiyan, OO Adesiyun, et al., Type 1 diabetes mellitus in the African population: epidemiology and management challenges. Acta Biomedica de l’Ateneo Parmense 2008:79:255–9.
GL Warne, J Raza. Disorders of sex development (DSDs), their presentation and management in different cultures. Reviews in Endocrine and Metabolic Disorders 2008;9:227–36. DOI: https://doi.org/10.1007/s11154-008-9084-2
OO Akinkugbe OO. Non-communicable diseases in Nigeria: the next epidemic. Niger J Clin Pract 2000;3:904-7.
S Kadir. Tackling cardiovascular disease in Africa. BMJ 2005;331:711-2. DOI: https://doi.org/10.1136/bmj.331.7519.711
IO Oluwayemi, AF Taiwo, To Ayeni. Eight Year Review of Paediatric Endocrine Cases Seen In Ekiti State University Teaching Hospital. Indian J Appl Res 2017;7:506-773.
AN Onyiruika, M Kouyaté. Paediatric endocrine disorders as seen at the University of Benin teaching hospital over a ten-year period. Niger J Paediatr 2014;41:316-20. DOI: https://doi.org/10.4314/njp.v41i4.5
OO Jarrett, BO Ogunbosi, OO Ayoola. Paediatric endocrine disorders at the university college hospital, Ibadan: 2002–2009. Ann Ib Postgrad Med 2013;11:96-101.
IJ Akinola , AO Afiemo, PO Ubuane, OA Odusote. Paediatric endocrine disorders at a tertiary hospital in Lagos, Nigeria. Niger J Paediatr 2022;49: 9–74. DOI: https://doi.org/10.4314/njp.v49i1.12
EE Oyenusi, EO Ajayi, FD Akeredolu, AO Oduwole. Pattern of thyroid disorders in children and adolescents seen at the Lagos University Teaching Hospital, Nigeria, over a 10-year period. Niger Med J 2017;58:101-6. DOI: https://doi.org/10.4103/nmj.NMJ_156_16
MU Ibekwe, RC Ibekwe. Pattern of Type 1 Diabetes Mellitus in Abakaliki, Southeastern, Nigeria. Pediatric Oncall. [serial online] 2011. Available from: http://www.pediatriconcall.com
OO Ayoola. Recent advances in childhood diabetes mellitus. Ann Ib Postgrad Med 2008;6:9‑20. DOI: https://doi.org/10.4314/aipm.v6i2.64046
ES Majaliwa, E Munubhi, K Ramaiya, et al. Survey on acute and chronic complications in children and adolescents with type 1 diabetes at Muhimbili National Hospital in Dar es Salaam, Tanzania. Diabetes Care 2007;30:2187‑92. DOI: https://doi.org/10.2337/dc07-0594
CF Otieno, JK Kayima, EO Omonge, GO Oyoo. Diabetic ketoacidosis: Risk factors, mechanisms and management strategies in sub‑Saharan Africa: A review. East Afr Med J 2005;82:S197‑203. DOI: https://doi.org/10.4314/eamj.v82i12.9382
R Unnikrishnan, R Pradeepa, SR Joshi, V Mohan . Type 2 diabetes: demystifying the global epidemic. Diabetes. 2017;66:1432-42. DOI: https://doi.org/10.2337/db16-0766
JL Hwang, RE Weiss. Steroidinduced diabetes: a clinical and molecular approach to understanding and treatment. Diabetes Metab Res Rev 2014;30:96-102. DOI: https://doi.org/10.1002/dmrr.2486
TR Bandgar, NS Shah. Thyroid disorders in childhood and adolescence. J Indian Med Assoc 2006;104:580-2.
S Leka-Emiri, GP Chrousos, C Kanaka-Gantenbein. The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). J Endocrinol Invest 2017;40:789-802. DOI: https://doi.org/10.1007/s40618-017-0627-9

How to Cite

Umar, Umar Isa. 2023. “Spectrum of Pediatric Endocrine Disorders at the Aminu Kano Teaching Hospital, Kano, Northwestern Nigeria: A Five-Year Review”. Pyramid Journal of Medicine 6 (1). https://doi.org/10.4081/pjm.2023.315.