Medico-social factors associated with late presentation in women with cancer of the cervix in Northern Nigeria

Submitted: 9 August 2019
Accepted: 28 January 2020
Published: 14 July 2021
Abstract Views: 179
PDF: 139
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Cancer of the cervix is the commonest gynecological cancer and the leading cause of cancer mortality among women in Africa.Certain social behaviors have been associated with an increased risk of high-risk Human Papillomavirus (HPV) infection, which is responsible for virtually all cases of Invasive Cervical Cancer (ICC). Retrospective review of the medico-social and histo-pathologic patterns of cases of cancer of the cervix at the Gynecology Oncology Unit, Aminu Kano Teaching Hospital, Kano between January 2006 to December 2010 was conducted. The socio-demographic, medical and histological data of each patient were extracted and analyzed. A total of 91 cases of cancer of the cervix were identified. The mean age of the respondents was 48 years (SD±10.2years), mean parity was 7 (SD±3.2) and mean age at first marriage was 15.2 years (SD±1.9years). Most of the patients had being married more than once in their lifetime. Majority of the women were unemployed and over half had no formal education. The commonest presenting complaint and complication respectively was vaginal bleeding (72.5%) and anaemia (45.1%). Most of the patient had advanced stages of the disease (86.8%). Only 18 out of the 91 had undergone HIV testing, with 28% testing positive to the virus. The commonest histologic type of cervical cancer (85.7%) was Squamous Cell Carcinoma (SCC). There were statistically significant associations between advanced disease and age, parity and number of lifetime marriages. Patients with cancer of the cervix seen at our institution are within the reproductive age group. They are mostly grandmultiparous, have no formal education and have more than one life time marriages. They usually present with late stage disease and of SCC histologically.

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Citations

Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer 2019;144:1941–53. DOI: https://doi.org/10.1002/ijc.31937
Munoz N, Bosch FX, Castellsaque X, et al. Against which human papilloma virus types shall we vaccinate and screen? The international perspective. Int J Cancer 2004;111:278-285. DOI: https://doi.org/10.1002/ijc.20244
Bosch FX, Sanjose S. Human papilloma virus and cervical cancer – Burden and Assessment of causality. J Natl cancer Inst 2003;31:3-13 DOI: https://doi.org/10.1093/oxfordjournals.jncimonographs.a003479
International Agency for Research on Cancer (IARC). Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 90. Human Papillomaviruses. Lyon (France): IARC; 2007.
IARC MonogrEval Carcinogen Risks Hum. Human Papillomaviruses 2007. International Agency for Research on Cancer: Lyon; Vol. 90.
Gaya SA, YakasaiIA, Muhammad AZ, et al. Cancer of the cervix in unscreened West African women. J Basic Clin Reprod Sci 2012;1:44-8. DOI: https://doi.org/10.4103/2278-960X.104296
Adewuyi SA, Shittu SO, Rafindadi AH. Socio-demographic and clinic-pathologic characterization of cervical cancers in northern Nigeria. Eur J Gynaec Oncol 2008;29:61-4.
Oguntayo AO, Zayyan M, Kolawole AOD, et al. Cancer of the cervix in Zaria, Northern Nigeria. eCancer 2011;5:219.
Ijaya MA, Aboyeji AP, Olatinwo AWO, Buhari MO. Clinico-pathological presentation of primary cervical cancer seen in Ilorin, Nigeria. Niger J Surg Res 2002;4:89–92. DOI: https://doi.org/10.4314/njsr.v4i3.12155
Bayo S, Bosch FX, de SanjoseS, et al. Risk factors of invasive cervical cancer in Mali. Int J Epidemiol 2002;31:202–9. DOI: https://doi.org/10.1093/ije/31.1.202
Louie KS, de Sanjose S, Diaz M, et al. Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries. Br J Cancer 2009;100: 1191-7. DOI: https://doi.org/10.1038/sj.bjc.6604974
Palefsky JM, Holly EA. Molecular virology and epidemiology of human papillomavirus and cervical cancer. Cancer Epidemiol Biomarkers Prevent 1998;4:425-8.
Palacio-Mejía LS, Range-Gomez G, Hernandez Avila M, et al. Cervical cancer, a disease of poverty: mortality difference between urban and rural areas in Mexico. Salud Pública de México 2003;45:S315–25. DOI: https://doi.org/10.1590/S0036-36342003000900005
Nour NM. Health Consequences of Child Marriage in Africa. Emerg Infect Dis 2006;12:1644-9. DOI: https://doi.org/10.3201/eid1211.060510
Anorlu RI. Cervical cancer: the sub-Saharan African perspective. Reprod Health Matters 2008;16:32:41-9. DOI: https://doi.org/10.1016/S0968-8080(08)32415-X
Hildesheim A, Herrero R, Castle PE, et al. HPV co-factors related to the development of cervical cancer: results from a population-based study in Costa Rica. Br J Cancer 2001;84:1219–26. DOI: https://doi.org/10.1054/bjoc.2001.1779
Munoz N, Franceschi S, Bosetti C, et al. Role of parity and human papillomavirus in cervical cancer. The IARC multicentre case-control study. Lancet 2002;359:1093–101. DOI: https://doi.org/10.1016/S0140-6736(02)08151-5
Denny L. The prevention of cervical cancer in the developing world. BJOG 2005;112:1204–12. DOI: https://doi.org/10.1111/j.1471-0528.2005.00713.x
Fonseca-Moutinho JA. Smoking and cervical cancer. ISRN Obstetr Gynecol 2011:847684. DOI: https://doi.org/10.5402/2011/847684
Mapanga W, Girdler-Brown B, Feresu SA, et al. Prevention of cervical cancer in HIV-seropositive women from developing countries through cervical cancer screening: a systematic review. Syst Rev 2018;7:198. DOI: https://doi.org/10.1186/s13643-018-0874-7
Smith Ho, Tiffany MF, Qualls Cr et al. The rising incidence of adenocarcinoma relative to squamous-cell carcinoma of the uterine cervix in the United States-A 24 year population-based study. Gyn Oncol 2000;78:97-105. DOI: https://doi.org/10.1006/gyno.2000.5826
Mandong BM, Ujah IA, Uguru VE. Clinico-pathological study of carcinoma of the cervix in Jos, Nigeria. Nig Med Pract 1997;34:76-9.

How to Cite

Gaya, Sule Abdullahi, Usman Aliyu Umar, Idris Usman Takai, and Sanusi Abubakar. 2021. “Medico-Social Factors Associated With Late Presentation in Women With Cancer of the Cervix in Northern Nigeria”. Pyramid Journal of Medicine 4 (1). https://doi.org/10.4081/pjm.2021.59.